Blockchain in Healthcare Global operates as 501c6 not-for-profit entity under the ISTO Federation.  The governing documents of the organization include its Bylaws, and Membership Agreement. All members upon joining the organization must sign the BiHG Membership Agreement that attests in writing that they have read and agree to abide by the terms of both the BiHG Bylaws.

The organization is governed also by its Board of Directors composed of Founding member delegates. The Board controls the direction of the organization and its operations as well as providing for the final decision-making body as it relates to Blockchain in Healthcare Global work products. Blockchain in Healthcare Global is structured as an open organization of multi-tiered members. Work group activity including proposals for new work groups, work group charters, projects, and work product is developed at the committee level, in turn, rolls up to the Board of Directors for final approval.